| Autor: |
Timothy S. Murbach, Róbert Glávits, Gábor Hirka, John R. Endres, Amy E. Clewell, Ilona Pasics Szakonyiné |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Toxicology Reports, Vol 4, Iss , Pp 494-501 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2214-7500 |
| DOI: |
10.1016/j.toxrep.2017.09.002 |
| Popis: |
Fernblock® is a standardized commercial aqueous extraction of the leaves of the tropical fern Polypodium leucotomos promoted as an orally active photoprotective substance. In a previous battery of toxicological tests on Fernblock®, no genotoxicy was observed and no oral toxicity was observed up to 1200 mg/kg bw/day. The current study was conducted in Hsd.Han Wistar rats using doses of 0, 2000, 3500, and 5000 mg/kg bw/day Fernblock® by gavage for 28 consecutive days. No mortality or toxic effects were observed and no target organs were identified. The no observed adverse effect level was determined to be 5000 mg/kg bw/day, the highest dose tested. Keywords: Polypodium leucotomos, Toxicology, Toxicity, Fernblock, NOAEL, Photoprotection |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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