| Autor: |
Vanessa Mara Chapla, Maria Luiza Zeraik, Valdecir F. Ximenes, Lisinéia Maria Zanardi, Márcia N. Lopes, Alberto José Cavalheiro, Dulce Helena S. Silva, Maria Cláudia M. Young, Luiz Marcos da Fonseca, Vanderlan S. Bolzani, Angela Regina Araújo |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 19, Iss 5, Pp 6597-6608 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules19056597 |
| Popis: |
Chemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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