Early increase in HbA1c trajectory predicts development of severe microangiopathy in patients with type 1 diabetes: the VISS study

Autor: Johnny Ludvigsson, Maria Nordwall, Hans J Arnqvist
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMJ Open Diabetes Research & Care, Vol 12, Iss 3 (2024)
Druh dokumentu: article
ISSN: 2052-4897
DOI: 10.1136/bmjdrc-2023-003917
Popis: Introduction To study the HbA1c trajectory from the time of diagnosis to examine if patients at the greatest risk for severe microangiopathy can be identified early allowing clinicians to intervene as soon as possible to avoid complications.Research design and methods In a population-based observational study, 447 patients diagnosed with type 1 diabetes before 35 years of age, 1983–1987, were followed from diagnosis until 2019. Mean HbA1c was calculated each year for each patient. Severe diabetic microangiopathy was defined as proliferative diabetic retinopathy (PDR) or macroalbuminuria (nephropathy).Results After 32 years, 27% had developed PDR and 8% macroalbuminuria. Patients with weighted HbA1c (wHbA1c);
Databáze: Directory of Open Access Journals