| Autor: |
Yuka Urano, Rintaro Ohe, Akane Yamada, Takanobu Kabasawa, Kazushi Suzuki, Takumi Kitaoka, Nobuyuki Tamazawa, Naing Ye Aung, Aya Utsunomiya, Tomomi Toubai, Kenichi Ishizawa |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Case Reports in Oncology, Vol 13, Iss 3, Pp 1145-1151 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1662-6575 |
| DOI: |
10.1159/000510362 |
| Popis: |
A 40-year-old man had been treated for Behçet’s disease (BD) with cyclosporine A (CsA) for 14 years. He presented multiple lymphadenopathies with fever. Histological examination of surgical biopsy showed other iatrogenic immunodeficiency-associated lymphoproliferative disorders, diffuse large B-cell lymphoma type with positivity for Epstein-Barr virus encoding RNA-1 (EBER-1). BCL2-IgH, BCL6-IgH, and MYC-IgH translocations were not detected. CsA was stopped, and R-CHOP therapy was initiated. However, his lymphoma was chemotherapy resistant and rapidly progressed. To the best of our knowledge, this is the first case of diffuse large B-cell lymphoma that occurred in a BD patient treated with CsA reported in English. Both BD and CsA are associated with the pathogenesis of lymphoma. We also describe extremely rare cases in the form of a literature review. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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