Sputum and plasma adiponectin levels in clinically stable adult cystic fibrosis patients with CFTR I1234V mutation

Autor: Atqah AbdulWahab, Mona Allangawi, Merlin Thomas, Ilham Bettahi, Siveen K. Sivaraman, Jayakumar Jerobin, Prem Chandra, Abdul-Badi Abou-Samra, Manjunath Ramanjaneya
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Translational Medicine Communications, Vol 5, Iss 1, Pp 1-7 (2020)
Druh dokumentu: article
ISSN: 2396-832X
DOI: 10.1186/s41231-020-00053-2
Popis: Abstract Background Cystic fibrosis (CF) lung disease is associated with chronic inflammation leading to progress in lung function. Adiponectin is a predominantly anti-inflammatory adipokine that may have a role in CF lung. This study aims to determine total sputum and total plasma adiponectin levels in clinically stable adults CF patients with CFTR I1234V mutation, compared to plasma adiponectin levels in healthy controls and to investigate their correlations with body mass index (BMI) and spirometry in patients with CF. Methods A cross-sectional study comprises 17 CF patients and 18 healthy controls. Adiponectin levels were measured by magnetic bead-based multiplex assay. Results The mean age of adult CF patients was 22.9 years±3.8 (18–30) and 76.5% CF patients had pancreatic sufficiency. The mean BMI in healthy controls was slightly higher than CF patients. The mean sputum adiponectin level was significantly lower than plasma adiponectin levels in CF patients and healthy controls (p
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