Oral administration of recombinant Bacillus subtilis spores expressing mutant staphylococcal enterotoxin B provides potent protection against lethal enterotoxin challenge

Autor:	Zhile Xiong, Jialiang Mai, Fei Li, Bingshao Liang, Shuwen Yao, Zhuwei Liang, Chao Zhang, Fei Gao, Xiaolan Ai, Jielin Wang, Yan Long, Min Yang, Sitang Gong, Zhenwen Zhou
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Staphylococcus aureus Staphylococcal enterotoxin B Vaccination Bacillus subtilis Biotechnology TP248.13-248.65 Microbiology QR1-502
Zdroj:	AMB Express, Vol 10, Iss 1, Pp 1-9 (2020)
Druh dokumentu:	article
ISSN:	2191-0855
DOI:	10.1186/s13568-020-01152-x
Popis:	Abstract Pathogenicity of Staphylococcus aureus is induced by staphylococcal enterotoxin B (SEB). A mutant form of SEB (mSEB) is immunogenic as well as less toxic. Recombinant mSEB and SEB were expressed in pET28a prokaryotic plasmids. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in mSEB-stimulated macrophages were lower than those in SEB-stimulated macrophages (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/65e4136d52014d8ba1eaf2afa1506be8 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.