| Autor: |
Chihiro Wakayama, Sachiko Inubushi, Tomonari Kunihisa, Sachiko Mizumoto, Motoi Baba, Hirokazu Tanino, Ik Sung Cho, Tooru Ooya |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
JCIS Open, Vol 9, Iss , Pp 100074- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-934X |
| DOI: |
10.1016/j.jciso.2023.100074 |
| Popis: |
Metal nanoparticles (NPs), such as gold NPs (AuNPs), are particularly sensitive to X-rays, and thus specific accumulation of AuNPs in a tumor would allow radiotherapy with low energy X-rays and reduced side effects. AuNPs can be generated using HAuCl4 and the natural polyphenol epigallocatechin-3-gallate (EGCG) in the presence of citrate. Here, we generated EGCG-AuNPs in the presence of several additives and examined the accumulation of these NPs in mouse tumors following intravenous administration. EGCG-AuNPs 15 nm in diameter in the presence of sodium alginate accumulated more in tumors compared to 40-nm-diameter EGCG-AuNPs. Furthermore, the results of in vitro cellular uptake and serum protein absorption studies suggest that adsorption of 15–16 kDa serum proteins to EGCG-AuNPs suppresses accumulation in tumors. Thus, tendency to adsorb specific proteins on EGCG-AuNPs surface should be tailored for enhancing their accumulation in tumors. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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