Respiratory Mechanics and Gas Exchange in Acute Respiratory Distress Syndrome Associated with COVID-19

Autor: R. A. Ibadov, D. M. Sabirov, S. Kh. Ibragimov, B. B. Burkhonov, R. R. Ibadov
Jazyk: English<br />Russian
Rok vydání: 2022
Předmět:
Zdroj: Общая реаниматология, Vol 18, Iss 5, Pp 24-31 (2022)
Druh dokumentu: article
ISSN: 1813-9779
2411-7110
DOI: 10.15360/1813-9779-2022-5-24-31
Popis: Aim. To compare respiratory mechanics and gas exchange in patients with acute respiratory distress syndrome (ARDS) with and without COVID-19.Material and methods. We examined 96 patients, who were divided into two groups. The main group included 48 patients with COVID-19-associated ARDS. The control group included 48 patients with ARDS not associated with COVID-19. Most characteristic patients were selected for the following baseline parameters: age, sex, SAPS II score, disease severity, plateau pressure (Pplateau), oxygenation index (PaO₂/FiO₂), and arterial-alveolar oxygen gradient (A-aO₂). Respiratory mechanics and gas exchange parameters assessed immediately after ARDS diagnosis and on days 1, 3 and 7 of treatment included arterial oxygen (PaO₂) and carbon dioxide (PaCO₂) pressure, tidal volume (Vt), respiratory rate (RR), respiratory minute volume (RMV), positive end expiratory pressure (PEEP), and Pplateau.Results. Patients in the main group had higher Vt (9.7 vs. 5.1 ml/kg, P
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