Autor: |
Dorothée Domenger, Juliette Caron, Yanath Belguesmia, Jean Lesage, Pascal Dhulster, Rozenn Ravallec, Benoit Cudennec |
Jazyk: |
angličtina |
Rok vydání: |
2017 |
Předmět: |
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Zdroj: |
Journal of Functional Foods, Vol 36, Iss , Pp 9-17 (2017) |
Druh dokumentu: |
article |
ISSN: |
1756-4646 |
DOI: |
10.1016/j.jff.2017.06.047 |
Popis: |
Food-derived hemorphins were studied for their interactions with intestinal cells in relation to food intake regulations. LLVV-H4, LVV-H4, VV-H4, VV-H7 and H7 were identified in the 2 h-intestinal hydrolysate of haemoglobin simulated gastrointestinal digestion and synthesised. These food-derived hemorphins showed secretagogue properties of the anorexigenic hormones cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) when in contact with murine STC-1 cells. They did not show significant modulatory effect on the corresponding prohormones mRNA levels. However, they downregulated the enzyme PC1 that processes proglucagon into GLP-1 specifically in the intestine. Moreover, VV-H4, VV-H7 & H7 were potent inhibitors of the GLP-1 inactivating dipeptidyl-peptidase IV (DPP-IV) and transiently upregulated its mRNA in human Caco-2 cells. These results suggest that food-derived hemorphins display dual luminal effects that participate at different levels in food intake and glycaemia regulation and add to the known roles of the special class of food-derived opioid peptides, the hemorphins. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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