| Autor: |
Bettina Heidecker, MD, Michelle M. Kittleson, MD, PhD, Edward K. Kasper, MD, Ilan S. Wittstein, MD, Hunter C. Champion, MD, PhD, Stuart D. Russell, MD, Kenneth L. Baughman, MD, Joshua M. Hare, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
JACC: Basic to Translational Science, Vol 1, Iss 3, Pp 107-121 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2452-302X |
| DOI: |
10.1016/j.jacbts.2016.02.001 |
| Popis: |
Over the last decades, beta-blockers have been a key component of heart failure therapy. However, currently there is no method to identify patients who will benefit from beta-blocking therapy versus those who will be unresponsive or worsen. Furthermore, there is an unmet need to better understand molecular mechanisms through which heart failure therapies, such as beta-blockers, improve cardiac function, in order to design novel targeted therapies. Solving these issues is an important step towards personalized medicine. Here, we present a comprehensive transcriptomic analysis of molecular pathways that are affected by beta-blocking agents and a transcriptomic biomarker to predict therapy response. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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