Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos Liquid-phase microextraction (LPME): fundamentals and applications to the analysis of drugs in biological samples
| Autor: | Anderson Rodrigo Moraes de Oliveira, Igor Rafael dos Santos Magalhães, Fernando José Malagueño de Santana, Pierina Sueli Bonato |
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| Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Química Nova, Vol 31, Iss 3, Pp 637-644 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0100-4042 1678-7064 58266445 |
| DOI: | 10.1590/S0100-40422008000300031 |
| Popis: | The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solid-phase extraction. Nevertheless, these extraction techniques are considered to be time-consuming and require a large amount of organic solvents. On this basis, microextraction techniques have been developed. Among them, liquid-phase microextraction has been standing out. This review describes the liquid-phase microextraction technique based on hollow fibers as a novel and promising alternative in sample preparation prior to chromatographic or electrophoretic analysis. The basic concepts related to this technique and its applicability in extraction of drugs are discussed. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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