Clinical and pathological features of idiopathic membranous nephropathy with focal segmental sclerosis

Autor: Jiatong Li, Bing Chen, Caifeng Gao, Jing Huang, Yongmei Wang, Shiyin Zhang, Ying Xu, Wenkai Guo, Rong Wang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Nephrology, Vol 20, Iss 1, Pp 1-10 (2019)
Druh dokumentu: article
ISSN: 1471-2369
DOI: 10.1186/s12882-019-1641-2
Popis: Abstract Background The goal of this study was to investigate the clinical and pathological features and prognosis of idiopathic membranous nephropathy (IMN) with focal segmental lesions. Methods In our hospital, 305 patients with nephrotic syndrome confirmed as IMN by renal biopsy were divided into a non-focal segmental lesion group (FSGS- group) and a focal segmental glomerulosclerosis (FSGS) group (FSGS+ group) and retrospectively analyzed. In all, 180 patients were followed for periods ranging from 6 months to 2 years. The general clinicopathological data of both groups were compared, and the effects of different treatment schemes on the prognosis of both groups were observed. Results The FSGS+ group had a longer disease course, higher blood pressure levels, and higher serum creatinine and β2-microglobulin levels than did the FSGS- group (all P
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