Peripheral Nerve Reconstruction Using Placental Connective Tissue Matrix to Alleviate Phantom Limb Pain: A Case Report

Autor: Eleanor Dunlap, Suzanna Fitzpatrick, Jeffery Lu, Georg J. Furtmüller, Khanjan Nagarsheth
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Annals of Vascular Surgery - Brief Reports and Innovations, Vol 3, Iss 2, Pp 100190- (2023)
Druh dokumentu: article
ISSN: 2772-6878
DOI: 10.1016/j.avsurg.2023.100190
Popis: Background: Phantom limb pain (PLP) complicates approximately 85% of patients who undergo major limb amputation. Studies consistently show that PLP significantly affects mobility, ability to perform tasks for daily living, and overall quality of life. Surgical treatments for PLP have been described in modern literature and do seem to offer promising results. In addition, recent studies have also described the use of placental connective tissue matrix (PCTM) to promote wound healing and nerve repairs. Methods: A retrospective chart review identified eights patients who underwent peripheral nerve reconstruction (PNR). This reconstruction included targeted muscle reinnervation (TMR) and wrapping of the nerve collections with PCTM, for chronic and debilitating PLP. Patient charts were reviewed for demographics, risk factors, current functional status, self-reported pre- and post-operative pain scale ratings, pre- and post-operative PROMIS scores for pain intensity, and vascular quality of life (QOL) scores. Results: Prior to PNR, each patient had undergone nerve block which relieved their PLP. Pre-operative and post-operative scores and values were recorded in each of the aforementioned categories. The numeric rating scale for pain assessment showed an average pre-operative pain score of 9.01 (range 8-10), post-operative score of 3.4 (range 1-6; p
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