Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial
| Autor: | Behdad Dehkhoda, Ayesheh Enayati, Hassan Mirzaei, Somayeh Ghorbani, Mohammad Hadi Soleimani, Saeid Amirkhanlou, Amirhossein Sahebkar |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Avicenna Journal of Phytomedicine, Vol 14, Iss 4, Pp 505-519 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2228-7930 2228-7949 |
| DOI: | 10.22038/ajp.2024.23871 |
| Popis: | Objective: The objective of this study was to evaluate theeffectiveness of Hibiscus sabdariffa L. extract (HS) as an adjunctto valsartan in the treatment of high blood pressure in patients withmild chronic kidney disease (CKD).Materials and Methods: This trial was conducted in Gorgan,Iran. Seventy-two participants with CKD and high blood pressurewere randomly assigned to either the HS group, receiving a 350mg pill every 12 hr for 90 days along with 40 mg of valsartanevery 12 hr, or the control group (40 mg valsartan + 12.5 mghydrochlorothiazide). The primary objective was to assess theimprovement of hypertension, while secondary objectives includedthe evaluation of proteinuria, albuminuria, kidney function, lipidprofile, and electrolyte levels. Molecular docking analysis wasperformed to examine the mechanisms of action of the isolatedcomponents of HS.Results: Out of 80 initial participants, 72 were included in theanalysis. Both groups showed a significant reduction in bloodpressure (p |
| Databáze: | Directory of Open Access Journals |
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