Anaerobe coverage is important for the prognosis of pyogenic liver abscess: A population-based study in Korea

Autor: Jun-Ho Myeong, Dae-Sung Kyoung, Min-Ae Park, Sang Gyune Kim, Young Seok Kim, Jeong-Ju Yoo, Min Jae Kim
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Infection and Public Health, Vol 15, Iss 4, Pp 425-432 (2022)
Druh dokumentu: article
ISSN: 1876-0341
DOI: 10.1016/j.jiph.2022.03.003
Popis: Background: Gram-negative bacteria such as Klebsiella pneumoniae and Escherichia coli are the most common cause of pyogenic liver abscess (PLA).We investigated whether the use of anaerobic-covering antibiotics is essential for the treatment of pyogenic liver abscess. Methods: We analyzed the Health Insurance Review and Assessment Service data in Korea between 2007 and 2017. We classified PLA into two groups: a group using antibiotics that inhibited only aerobic strains (anaerobe (-) group) and a group using antibiotics that inhibited both aerobic and anaerobic strains (anaerobe (+) group). The primary outcome was the difference in in-hospital mortality between the two groups. Results: During this period, a total of 30,690 PLA patients were obtained. There were 6733 patients in the anaerobe (-) group and 23,957 patients in the anaerobe (+) group. In-hospital mortality was significantly lower in the anaerobe (+) group than the anaerobe (-) group (7.9% vs. 15.6%, p
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