The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson’s disease
Autor: | Carolin Gabbert, Leonie Blöbaum, Theresa Lüth, Inke R. König, Amke Caliebe, Sebastian Sendel, Björn-Hergen Laabs, Christine Klein, Joanne Trinh |
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Jazyk: | angličtina |
Rok vydání: | 2024 |
Předmět: | |
Zdroj: | Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024) |
Druh dokumentu: | article |
ISSN: | 2045-2322 44975422 |
DOI: | 10.1038/s41598-024-65640-x |
Popis: | Abstract The objective of this study was to investigate the association between a Parkinson’s disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. We included data from 4367 patients with idiopathic PD, 159 patients with GBA1-PD, and 3090 healthy controls of European ancestry from AMP-PD, PPMI, and Fox Insight cohorts. The association between PGS and lifestyle factors on AAO was assessed with linear and Cox proportional hazards models. The PGS showed a negative association with AAO (β = − 1.07, p = 6 × 10–7) in patients with idiopathic PD. The use of one, two, or three of the protective lifestyle factors showed a reduction in the hazard ratio by 21% (p = 0.0001), 44% (p 0.05). In our cohort, coffee, tobacco, aspirin, and PGS are independent predictors of PD AAO. Additionally, lifestyle factors seem to have a greater influence on AAO than common genetic risk variants with aspirin presenting the largest effect. |
Databáze: | Directory of Open Access Journals |
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