Prognostic Value of Microvessel Density in Tumor and Peritumoral Area as Evaluated by CD31 Protein Expression and Argyrophilic Nucleolar Organizer Region Count in Endothelial Cells in Uterine Leiomyosarcoma
| Autor: | Ashot Avdalyan, Igor Bobrov, Vladimir Klimachev, Alexander Lazarev |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Sarcoma, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1357-714X 1369-1643 |
| DOI: | 10.1155/2012/594512 |
| Popis: | The objective of this study was to investigate the prognostic value of microvessel density (MVD) in uterine leiomyosarcoma (LMS) and peritumoral area (PA) as evaluated by CD31 expression and argyrophilic nucleolar organizer region (AgNOR) count in endothelial cells. Tissue specimens from 66 patients with uterine LMS were examined. There were no significant differences in the mean MVD between tumor itself and the PA (𝑃=0.9); moreover, the MVD in the PA often exceeded that in the tumor. No correlation or significant differences were also found in the MVD between different grades of malignancy of LMS (𝑟=0.1; 𝑃=0.07). The number of AgNORs in tumor endothelial cells was significantly higher in tumor vessels than in the peritumoral area (𝑃 |
| Databáze: | Directory of Open Access Journals |
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