| Autor: |
Xue Dong, MD, PhD, Ishani Premaratne, BA, Mariam Gadjiko, BA, Nabih Berri, MD, Skander Limem, PhD, Kemal Sariibrahimoglu, PhD, Jeffrey Scott, PhD, Jason Spector, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Plastic and Reconstructive Surgery, Global Open, Vol 9, Iss 7S, Pp 42-42 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2169-7574 |
| DOI: |
10.1097/01.GOX.0000770156.97404.18 |
| Popis: |
Purpose: Nipple reconstruction is a vital part of breast reconstruction after total mastectomy. However, nearly all autologous tissue techniques utilized for reconstruction of the nipple are hindered by scar contracture and loss of projection of the neo-nipple. Unfortunately, engineered tissue substitutes, such as Cook Biodesign® nipple reconstruction cylinders, have demonstrated suboptimal projection maintenance over time. Costal cartilage (CC) has been described in nipple reconstruction to maintain projection, yet has not been adopted due to the excessively firm nipple that results. Herein we propose using 3D-printed bioabsorbable P4HB (3D-P4HB) scaffolds loaded with processed CC in order to foster ingrowth of tissue that mimics the biomechanical properties of native nipples and to protect the regenerated tissue from contracture as it matures. Methods: 3D-P4HB scaffolds (diameter: 1.0cm, height: 1.0cm) were fabricated and sterilized. Patient-derived CC (discarded from DIEP procedures) was either minced (1mm3) or zested (0.05). Conclusion: Using 3D-P4HB scaffolds filled with autologous processed CC, we have engineered nipples that maintain their projection and volume over time, while simultaneously allowing for the maturation of an internal structure of fibrovascular cartilaginous tissue that biomechanically mimics that of native nipples. As the 3D-P4HB scaffold gradually absorbs, data suggest that newly-regenerated tissue may resist scar contracture and maintain projection over time. Because P4HB devices for soft tissue reinforcement have previously been cleared by the FDA and possess a long track record of safety, we believe that this novel 3D-P4HB nipple reconstruction scaffold may be readily translatable to the clinic. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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