Synthesis of a Dual-Color Fluorescent Dendrimer for Diagnosis of Cancer Metastasis in Lymph Nodes

Autor:	Chie Kojima, Kento Nagai
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	dendrimer dual color fluorescence imaging lymph node tumor cells Organic chemistry QD241-441
Zdroj:	Polymers, Vol 14, Iss 20, p 4314 (2022)
Druh dokumentu:	article
ISSN:	2073-4360
DOI:	10.3390/polym14204314
Popis:	Detection of cancer metastasis spread in lymph nodes is important in cancer diagnosis. In this study, a fluorescence imaging probe was designed for the detection of both lymph node and tumor cells using always-ON and activatable fluorescence probes with different colors. Rhodamine B (Rho), a matrix metalloproteinase−2 (MMP−2)-responsive green fluorescence probe, and a tumor-homing peptide were conjugated to a carboxy-terminal dendrimer that readily accumulates in lymph nodes. The activatable green fluorescence signal increased in the presence of MMP−2, which is secreted by tumor cells. Both the always-ON Rho signal and the activatable green fluorescence signal were observed from tumor cells, but only the weak always-ON Rho signal was from immune cells. Thus, this type of dendrimer may be useful for non-invasive imaging to diagnose cancer metastasis in lymph nodes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/60fbb681dbc6465d83331116c081182b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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