Second-Trimester Constituents of the Metabolic Syndrome and Pregnancy Outcome: An Observational Cohort Study

Autor: Jonas Ellerbrock, Esmee Hubers, Chahinda Ghossein-Doha, Veronique Schiffer, Robert-Jan Alers, Laura Jorissen, Jolijn van Neer, Maartje Zelis, Emma Janssen, Sabine Landewé-Cleuren, Annemie van Haarlem, Boris Kramer, Marc Spaanderman
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nutrients, Vol 14, Iss 14, p 2933 (2022)
Druh dokumentu: article
ISSN: 2072-6643
DOI: 10.3390/nu14142933
Popis: Background: Gestational diabetes mellitus (GDM) increases the risk of type 2 diabetes mellitus and cardiovascular disease (CVD) in women in later life. In the general population, metabolic syndrome (MetS) shows identical associations. The aim of this study was to evaluate the association between GDM, constituents of MetS and pregnancy outcomes. Methods: Of 2041 pregnant women undergoing an oral glucose tolerance test (OGTT) between 22 and 30 weeks of gestation, data were collected to evaluate the constituents of MetS. Odds ratios (ORs) were calculated to determine the associations between MetS and pregnancy outcomes. Results: GDM and obesity did not affect the risk of fetal growth abnormalities (SGA/LGA), preterm birth or preeclampsia (PE). Hypertension significantly increased the risk of SGA (OR—1.59), PE (OR—3.14), and preterm birth
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