Correlation between antimicrobial resistant Propionibacterium acnes and severity of acne vulgaris: Findings from a tertiary hospital

Autor: Maria Mayfinna Gozali, Yuli Kurniawati, Mutia Devi, Erial Bahar, Lisa Dewi, Yulia Farida Yahya, Rusmawardiana, Sarah Diba Zulkarnain, Soenarto Kartowigno
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Indian Journal of Dermatology, Vol 68, Iss 4, Pp 488-488 (2023)
Druh dokumentu: article
ISSN: 0019-5154
1998-3611
DOI: 10.4103/ijd.ijd_623_22
Popis: The study of antimicrobial-resistant Propionibacterium acnes was not conducted regularly, especially in Indonesia. Conversely, regular monitoring of antibiotic efficacy through in vitro testing to assess the evolution of current resistance patterns is obligated; thus, filling the gap caused by a lack of appropriate antibiotic surveillance is required. Analyse the correlation between resistance patterns of P. acnes to doxycycline, clindamycin, erythromycin and azithromycin with the severity of acne vulgaris. This is an analytic observational laboratory study with a cross-sectional design of mild to severe acne vulgaris (AV) patients. Specimens were obtained from comedones of 71 patients, which were cultured and identified using biochemical examination. Antimicrobial resistance (doxycycline, clindamycin, erythromycin and azithromycin) to P. acnes was tested by disc diffusion method. Among 71 samples collected, 40 (56.3%) P. acnes isolates were cultured and identified. The incidence of P. acnes resistance to more than one antimicrobial was 45%. Antimicrobial resistances were clindamycin 42.5%, erythromycin 40%, azithromycin 23.5% and doxycycline 12.5%, respectively. According to the contingency coefficient test, there was moderate correlation between the resistance pattern of P. acnes to clindamycin (r = 0.485, P =
Databáze: Directory of Open Access Journals
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