Periodontal Regeneration of Intrabony Defects in Animal Models Using Biologic Modifiers: A Systematic Review and Meta-analysis
| Autor: | Zeynab Farimani, Mojgan Paknejad, Mahboubeh Bohlouli, Navid Yousefi, Neda Izadi, Soolmaz Akbari |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 30, Iss 194, Pp 171-185 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: The ultimate goal in periodontal treatment is to achieve a functional and anatomical regeneration of lost tissues. Due to the promising outcomes of biologic modifiers in regenerative therapies, this systematic review aimed at evaluating the effects of various biologic modifiers used in intra-bony osseous defects in animal models. Materials and methods: Electronic databases were searched for articles published in March 2010-March 2020 that had evaluated the effect of bio-modifiers used in periodontal intra-bony osseous defects in animal models. Screening was performed based on inclusion/exclusion criteria and SYRCLE tool was used for studies’ quality assessment. Results: After screening the titles, abstracts, and full-texts, 18 studies were included in qualitative analysis and five studies entered the meta-analysis. According to the configuration of osseous defects, the studies were categorized into three subgroups. Based on histological findings, all these biologic markers significantly enhanced new bone and cementum formation compared to control groups (P |
| Databáze: | Directory of Open Access Journals |
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