Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor

Autor:	Elise Bouffard, Chiara Mauriello Jimenez, Khaled El Cheikh, Marie Maynadier, Ilaria Basile, Laurence Raehm, Christophe Nguyen, Magali Gary-Bobo, Marcel Garcia, Jean-Olivier Durand, Alain Morère
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	mannose 6-phosphate analogues binding affinity mesoporous silica nanoparticles photodynamic therapy Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 20, Iss 11, p 2809 (2019)
Druh dokumentu:	article
ISSN:	1422-0067
DOI:	10.3390/ijms20112809
Popis:	The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the targeting of the cation-independent mannose 6-phosphate receptor, which is overexpressed in prostate cancer. This original sugar, a dimannoside-carboxylate (M6C-Man) grafted on the surface of MSN for PDT applications, leads to a higher endocytosis and thus increases the efficacy of MSNs.
Databáze:	Directory of Open Access Journals
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