| Autor: |
Soledad Baños-Mateos, Anne-Marie M. van Roon, Ulla F. Lang, Sarah L. Maslen, J. Mark Skehel, Meindert H. Lamers |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-017-00886-w |
| Popis: |
The polymerase and histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high-fidelity DNA replication. Here, the authors determine the DnaE1 crystal structure, which reveals the PHP-exonuclease mechanism that can be exploited for antibiotic development. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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