| Autor: |
Lin Li, Dongfan Chen, Jiale Chen, Chao Yang, Youyun Zeng, Ting Jin, Yanmei Zhang, Xiaoyu Sun, Hongli Mao, Zhixiang Mu, Xinkun Shen, Zhanwei Ruan, Xiaojun Cai |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Materials & Design, Vol 229, Iss , Pp 111927- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0264-1275 |
| DOI: |
10.1016/j.matdes.2023.111927 |
| Popis: |
The development of functional wound dressings capable of both rapid hemostasis and high-efficiency antimicrobial is essential for the management of severe bleeding wounds. Cotton dressings are widely used in clinical practice; however, few dressings can simultaneously achieve rapid hemostasis and high-efficacy antimicrobial. Herein, a versatile cotton dressing (GCQCNF-5) was masterly developed by sequentially deposition catechol modified quaternary chitosan (CQCS) and gelatin onto a cotton nonwoven fabric (NF) surface. Because of the presence of a gelatin sponge layer with suitable thickness and porosity on its surface, GCQCNF-5 exhibits a notably enhanced hemostatic effect compared to NF both in vitro and in vivo, which is even slightly superior to that of MHS (a commercial gelatin hemostatic sponge). Moreover, after exerting a rapid hemostasis effect, GCQCNF-5 can further exploit CQCS to exert excellent immediate antimicrobial and long-lasting bacteriostatic effects. In vivo wound healing experiments further indicated that GCQCNF-5 could significantly promote rapid healing of infected wounds by effectively sterilizing, absorbing exudates, and providing moist healing environments. This study clearly demonstrated that GCQCNF-5 is a versatile wound dressing that can achieve simultaneously rapid hemostasis, high-efficiency antimicrobial, and promote rapid healing of infected wounds, with great application potential for the treatment of severe bleeding wounds. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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