The DIVE/DPV registries: evolution of empagliflozin use in clinical practice in Germany

Autor: Thomas Danne, Jochen Seufert, Christian Wagner, Kerstin König, Dirk Raddatz, Rosmarie Weber-Lauffer, Diether Erath, Jost Hilgenberg, Carsten Spies, Maximilian Gabler, Johannes Foersch, Ludwin Ley
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Druh dokumentu: article
ISSN: 2052-4897
DOI: 10.1136/bmjdrc-2020-001486
Popis: Introduction Empagliflozin reduced morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) in clinical trials. A registry study was undertaken to describe evolution of patient characteristics and assess the real-world effectiveness/safety of empagliflozin.Research design and methods Data from the Diabetes Patienten Verlaufsdokumentation (DPV)/Diabetes Versorgungsevaluation (DIVE) registries on 9571 adults with T2DM (registered in 2014–2019) receiving empagliflozin were used. Patients were grouped according to the following: early users (group 1; n=505) received empagliflozin before the EMPA-REG OUTCOME study publication (mid-September 2015); intermediate users (group 2; n=2961) started empagliflozin after the EMPA-REG OUTCOME publication but before the European Medicines Agency label change (from mid-September 2015 to mid-January 2017); and late users (group 3; n=6105) started empagliflozin after mid-January 2017. Data on clinical and treatment characteristics were collected.Results Over time, the proportion of recipients aged
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