Development of New Composite Materials by Modifying the Surface of Porous Hydroxyapatite Using Cucurbit[n]urils

Autor:	Tolkynay Burkhanbayeva, Arthur Ukhov, Dmitry Fedorishin, Alexander Gubankov, Irina Kurzina, Abdigali Bakibaev, Rakhmetulla Yerkassov, Togzhan Mashan, Faiziya Suyundikova, Nurgul Nurmukhanbetova, Aina Khamitova
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	biocompatible materials hydroxyapatite cucurbit[n]urils cytotoxicity hemolytic activity anti-inflammatory effect Technology Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Zdroj:	Materials, Vol 17, Iss 9, p 2041 (2024)
Druh dokumentu:	article
ISSN:	1996-1944 31667147
DOI:	10.3390/ma17092041
Popis:	This study represents an advancement in the field of composite material engineering, focusing on the synthesis of composite materials derived from porous hydroxyapatite via surface modification employing cucurbit[n]urils, which are highly promising macrocyclic compounds. The surface modification procedure entailed the application of cucurbit[n]urils in an aqueous medium onto the hydroxyapatite surface. A comprehensive characterization of the resulting materials was undertaken, employing analytical techniques including infrared (IR) spectroscopy and scanning electron microscopy (SEM). Subsequently, the materials were subjected to rigorous evaluation for their hemolytic effect, anti-inflammatory properties, and cytotoxicity. Remarkably, the findings revealed a notable absence of typical hemolytic effects in materials incorporating surface-bound cucurbit[n]urils. This observation underscores the potential of these modified materials as biocompatible alternatives. Notably, this discovery presents a promising avenue for the fabrication of resilient and efficient biocomposites, offering a viable alternative to conventional approaches. Furthermore, these findings hint at the prospect of employing supramolecular strategies involving encapsulated cucurbit[n]urils in analogous processes. This suggests a novel direction for further research, potentially unlocking new frontiers in material engineering through the exploitation of supramolecular interactions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5f3b1d31667147ad9a496fab2d294815 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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