Effect of Ethanolic Extract of Mespilus germanica on Cutaneous Leishmaniasis in BALB/c Mice
| Autor: | N Shariatifar, R Rahimnia, AM Jamshidi, M Pirali Hamedani, Sh Shoeibi |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Journal of Medicinal Plants, Vol 10, Iss 39, Pp 76-81 (2011) |
| Druh dokumentu: | article |
| ISSN: | 2717-204X 2717-2058 |
| Popis: | Background: Leishmaniasis is a vector-borne disease caused by flagellated protozoan parasites of the genus Leishmania, which affects both humans and other mammals. Most of the available drugs against the disease are toxic and some are parasite resistance to them. Objective: The purpose of this study was to examine the effect of Mespilus germanica extract on cutaneous leishmaniasis (CL) in BALB/c Mice. Methods: Ethanolic extract of Mespilus germanica with 40, 60 and 80% concentrations were prepared. Then, the BALB/c mice were inoculated subcutaneously by 0.1 ml liquid phase culture containing promastigotes of Leishmania major. Ethanolic extract of the leaves of Mespilus germanica in different concentrations, were used topically on CL lesions. Results: The mean diameter of the lesions were decreased, and also the number of parasites in the lesions had declined with complete healing by ending the period time of treatment in 4 mice (26.7%), (p< 0.05) and in 9 animals (82%), (p |
| Databáze: | Directory of Open Access Journals |
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