| Autor: |
Jianjiang Qi, Di He, Dagan Yang, Mengyan Wang, Wenjun Ma, Huaizhong Cui, Fei Ye, Fei Wang, Jinjian Xu, Zhijian Li, Chuntao Liu, Jing Wu, Kexin Qi, Rui Wu, Jinsong Huang, Shourong Liu, Yimin Zhu |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2334 |
| DOI: |
10.1186/s12879-021-06509-6 |
| Popis: |
Abstract Background The severity of COVID-19 associates with the clinical decision making and the prognosis of COVID-19 patients, therefore, early identification of patients who are likely to develop severe or critical COVID-19 is critical in clinical practice. The aim of this study was to screen severity-associated markers and construct an assessment model for predicting the severity of COVID-19. Methods 172 confirmed COVID-19 patients were enrolled from two designated hospitals in Hangzhou, China. Ordinal logistic regression was used to screen severity-associated markers. Least Absolute Shrinkage and Selection Operator (LASSO) regression was performed for further feature selection. Assessment models were constructed using logistic regression, ridge regression, support vector machine and random forest. The area under the receiver operator characteristic curve (AUROC) was used to evaluate the performance of different models. Internal validation was performed by using bootstrap with 500 re-sampling in the training set, and external validation was performed in the validation set for the four models, respectively. Results Age, comorbidity, fever, and 18 laboratory markers were associated with the severity of COVID-19 (all P values |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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