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Rhizoctonia bataticola is an anamorphic phytopathogenic fungus which acts as facultative plant pathogens causing diseases to commercially important crops. The fungal metabolite analysis for pharmaceutical importance, mycotoxin characterization and taxonomy of industrially and medically important fungi is in need. Therefore, in the present work isolation and characterization of metabolites from Rhizoctonia bataticola and their biological activities were evaluated. The extract of Rhizoctonia bataticola showed strong antibacterial activity against gram-positive S. aureus and gram-negative E. coli bacteria. The increased in concentration of fungal extract reports increased in antibacterial and antioxidant activity. The extract of solid biomass was analyzed by LC-MS and first time reported 33 compounds including Dadezin, Genkwanin, Pentoxifylline alcohol, Dihydrodeoxystreptomycin, 8-Cyclopentyltheophyllin, Protorifamycin 1, Leukotriene D4, Protoveratrine A, Phedimetrazine as important ones. Among the reported compounds most of the compounds shows pharmacological properties like antileukemic activity, cardioprotective, anticancer, antifungal activity, antimicrobial activity, antihypertensive, anti-hypogonadal, and radical scavenging activities. Therefore, reported metabolite from fungal extract supports the biological activities. However further isolation and characterization of bioactive compounds from Rhizoctonia bataticola emerge as a potent source of bioactive compounds with potent bioactivities and can be help in solving bacterial multi-drug resistance in human pathogenic bacteria. |
