Chemical Constituents with Anti-Proliferative Activity on Pulmonary Arterial Smooth Muscle Cells from the Roots of Anthriscus sylvestris (L.) Hoffm.

Autor:	Yanling Liu, Yangang Cao, Yajuan Zheng, Ying Niu, Lan Chen, Xu Chen, Xinyi Ma, Xiangda Li, Xiaoke Zheng, Weisheng Feng
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Anthriscus sylvestris phenylpropanoid phenol glycoside anti-proliferative activity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 29, Iss 11, p 2547 (2024)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules29112547
Popis:	A chemical investigation of Anthriscus sylvestris roots led to the isolation and characterization of two new nitrogen-containing phenylpropanoids (1–2) and two new phenol glycosides (8–9), along with fifteen known analogues. Structure elucidation was based on HRESIMS, 1D and 2D NMR spectroscopy, and electronic circular dichroism (ECD). In addition, compounds 3, 6, 9–10, 12, and 17 exhibited inhibitory effects against the abnormal proliferation of pulmonary arterial smooth muscle cells with IC50 values ranging from 10.7 ± 0.6 to 57.1 ± 1.1 μM.
Databáze:	Directory of Open Access Journals
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