Clinical features and genetic biomarkers associated with different phenotypes of systemic lupus erythematosus in Paraguayan patients
| Autor: | I. Acosta-Colman, Z. Morel, A. Ayala Lugo, V. Jolly, I. de Guillén, P. Langjahr, M. Vazquez, M.T Martínez de Filártiga, M.E. Acosta |
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| Jazyk: | English<br />Italian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Reumatismo, Vol 75, Iss 2 (2023) |
| Druh dokumentu: | article |
| ISSN: | 0048-7449 2240-2683 |
| DOI: | 10.4081/reumatismo.2023.1541 |
| Popis: | Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a heterogeneous clinical picture that makes the diagnosis and follow-up of these patients difficult. This study aimed to identify correlations between clinical, immunological, and genetic biomarkers and clinical manifestations in SLE. A retrospective study of data from medical records and immunological and genetic studies of SLE patients in Paraguay was carried out. A descriptive analysis was performed based on the type of variable. Human leukocyte antigen (HLA) allele frequencies (DPA1, DPB1, DQA1, DQB1, and DRB1) were calculated, and univariate logistic regression analyses were performed between each of the explanatory variables and the presence or absence of each phenotype. Odds ratios, 95% confidence intervals, and p values were recorded. Associations with p |
| Databáze: | Directory of Open Access Journals |
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