Hibiscus sabdariffa fractions attenuate oxidative stress and some cardiac biomarkers in sodium fluoride(NaF)-induced cardiotoxicity rat

Autor: Juliana B. Adetunji, Oluwaseun A. Adebisi, Israel O. Adeyomoye, Sunday I. Oyeleye, Daniel O. Adebayo, Ikechukwu P. Ejidike
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Taibah University for Science, Vol 17, Iss 1 (2023)
Druh dokumentu: article
ISSN: 16583655
1658-3655
DOI: 10.1080/16583655.2023.2202164
Popis: The excessive intake and bioaccumulation of sodium fluoride (NaF) through water, toothpaste or pesticides could trigger cardiac oxidative stress. The effects of Hibiscus sabdariffa (HS) fractions on biochemical markers of the heart in NaF-induced rats. Thirty male and female rats were grouped into five: Normal control (NC) received water only, Sodium fluoride (NaF, 300 mg L−1), the others were exposed to 300 mg L−1 NaF while the treated animals received100 mg kg−1d−1 of aqueous, n-hexane and butanol -H. sabdariffa (AQE-HS, HEE-HS, BTE-HS) fractions orally for 14 days respectively. This study revealed that NaF exposure increases TBARS, TC, TG, LDL-c, AI, AC, CRI-I, CRI-II and arginase activity with a decrease in catalase, GST, SOD, GSH, HDL-c, and NO level whilethe HS treatment stimulates antioxidant production which eventually reduce oxidative stress. The AQE-HS suppressed TBARS, lipid profile, and cardiac indices. Therefore, bioactive constituent of HS attenuates NAF-induced cardiac oxidative stress.
Databáze: Directory of Open Access Journals
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