Large T‐cell extradural lymphoma with concurrent marked cerebrospinal fluid eosinophilia in a dog

Autor: Anna M. Massie, Katherine Skorupski, William Vernau, Ehren McLarty, Rachel V. Brady, Karen M. Vernau
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 37, Iss 6, Pp 2492-2497 (2023)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16854
Popis: Abstract A 3‐year‐old male pit bull terrier was presented for a 4‐day history of progressive tetraparesis and cervical pain. Magnetic resonance imaging confirmed an extradural mass within the left lateral vertebral canal extending from caudal C5 to mid‐T2. Lumbar cerebrospinal fluid (CSF) demonstrated marked (90%) eosinophilic inflammation. A C6‐7 dorsal laminectomy and C7‐T2 left hemilaminectomy were done, with gross disease remaining. Histopathology revealed a large T cell lymphoma with marked eosinophilic infiltration. The dog underwent CHOP‐based chemotherapy with resolution of clinical signs, with a similar course of therapy performed at recurrence 37 months after initial presentation. The dog was euthanized 39 months after presentation for multiorgan failure secondary to neutropenic sepsis and aspiration pneumonia. This represents a positive long‐term response to multimodal treatment of extradural T‐cell lymphoma within the vertebral canal associated with a marked CSF eosinophilia.
Databáze: Directory of Open Access Journals
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