A Pilot Study of Possible Easy-to-Use Electrophysiological Index for Early Detection of Antidepressive Treatment Non-Response

Autor: Goded Shahaf, Shahak Yariv, Boaz Bloch, Uri Nitzan, Aviv Segev, Alon Reshef, Yuval Bloch
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Frontiers in Psychiatry, Vol 8 (2017)
Druh dokumentu: article
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2017.00128
Popis: IntroductionThe evaluation of response to pharmacological treatment in MDD requires 4–8 weeks. Therefore, the ability to predict response, and especially lack of response to treatment, as early as possible after treatment onset or change, is of prime significance. Many studies have demonstrated significant results regarding the ability to use EEG and ERP markers, including attention-associated markers such as P300, for early prediction of response to treatment. But these markers are derived from long EEG/ERP samples, often from multiple channels, which render them impractical for frequent sampling.Methods and resultsWe developed a new electrophysiological attention-associated marker from a single channel (two electrodes), using 1-min samples with auditory oddball stimuli. This work presents an initial evaluation of the ability to use this marker’s dynamics between repetitive measures for early (
Databáze: Directory of Open Access Journals