Isolation, Structural Analysis and Biological Activity Assays of Biselisabethoxanes A and B: Two Dissymmetric Bis-Diterpenes from the Southwestern Caribbean Sea Gorgonian Coral Pseudopterogorgia elisabethae

Autor:	Ileana I. Rodríguez, Abimael D. Rodríguez, Charles L. Barnes
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Pseudopterogorgia elisabethae biselisabethoxanes hetero-Diels-Alder reaction bis-diterpenes diterpene dimers gorgonian octocoral Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 22, p 7879 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27227879
Popis:	Two novel dissymmetric diterpenoids, biselisabethoxanes A and B (1 and 2), were isolated from the hexane extracts of the gorgonian coral Pseudopterogorgia elisabethae. Biselisabethoxane A (1) represents the first example of a marine-derived C40 dimer made of two distinct diterpene fragments, whereas biselisabethoxane B (2) is a fused heterodimer stemming from coupling of two amphilectane-based fragments. The structures of 1 and 2 were elucidated based on 1D and 2D NMR spectral data analysis. The molecular structure of 1 was subsequently confirmed by X-ray crystallographic analysis. When evaluated for their inhibitory effects in a series of well-established biological activity assays the isolated compounds were shown to moderately inhibit the growth of Mycobacterium tuberculosis.
Databáze:	Directory of Open Access Journals
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