| Autor: |
Melissa Ameloti Gomes Avelino, Isabela Jubé Wastowski, Ricardo Gimenes Ferri, Thaís Gomes Abrahão Elias, Ana Paula Lindoso Lima, Larissa Cardoso Marinho, Shirley Shizue Nagata Pignatari |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Otorhinolaryngology, Vol 80, Iss 3, Pp 208-212 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1808-8686 |
| DOI: |
10.1016/j.bjorl.2014.01.001 |
| Popis: |
INTRODUCTION: Sinonasal polyposis (NP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. HLA-G molecules are a kind of no classic class I antigen with anti-inflammatory and tolerogenic properties. Little attention has been paid to the role of HLA-G chronic inflammatory disorders. OBJECTIVE: The aim of this study is to investigate the expression of HLA-G in the NP. MATERIALS AND METHODS: Prospective study involving samples of patients presenting with nasal polyposis that were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups and classified as asthmatic or non-asthmatic. RESULTS: Immunohistochemical staining demonstrated a higher expression of the HLA-G molecule in samples from nonatopic than in those from atopic patients, and was significantly lower in the non-asthmatic patients. CONCLUSION: These results indicate that HLA-G may play an important role in the pathology of nasal polyposis. Considering the anti-inflammatory properties of HLA-G, this study suggests that it could reduce susceptibility to atopy and asthma. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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