| Autor: |
Zhenyi Huang, Yawei Wang, Shikun Feng, Yanmin Zhang, Xindang Zhang, Xulu Chang, Guokun Yang, Xiaolin Meng |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Aquaculture Reports, Vol 38, Iss , Pp 102363- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2352-5134 |
| DOI: |
10.1016/j.aqrep.2024.102363 |
| Popis: |
Akkermansia muciniphila (Akk) is an important probiotic that can help alleviate metabolic disorders. Recent research indicates that pasteurized Akkermansia muciniphila (P-Akk) is even more effective. To investigate the effect of P-Akk on improving lipid metabolism disorders caused by a high-fat diet (HFD) in fish, zebrafish were fed two HFDs containing 0 (HFD group, as control) and 1 × 109 CFU/g P-Akk (P-Akk group) for 28 days. The addition of P-Akk significantly decreased the number of lipid droplets in the liver and improved the mitochondrial structure in the intestine, while also altering gene expression related to lipid metabolism in HFD-fed zebrafish. Furthermore, intestinal transcriptomic network analysis and results from primary intestinal cells indicated that P-Akk may enhance mitochondrial function by activating the AMPK/PGC1α pathway. Although P-Akk did not significantly alter the composition of the gut microbiota, it did increase the steady-state index of intestinal microbiota. Moreover, P-Akk upregulated the abundance of beneficial probiotics, (Plesiomonas, Cetobacterium, and Bacillus), while downregulating the abundance of pathogens (Aeromonas, Pseudomonas, Acinetobacter, and Streptococcus). Collectively, these findings indicate that P-Akk has the potential to serve as a green and safe feed additive for improving HFD-induced lipid metabolism disorders in fish. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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