| Autor: |
Miki Arai Hojo, Kyoko Masuda, Hiroaki Hojo, Yosuke Nagahata, Keiko Yasuda, Daiya Ohara, Yusuke Takeuchi, Keiji Hirota, Yutaka Suzuki, Hiroshi Kawamoto, Shinpei Kawaoka |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-10525-1 |
| Popis: |
Autoreactive T cells are deleted in the thymus via thymic negative selection and Bim-mediated apoptosis. Here the authors identify a cis-acting enhancer, E BAB , that is essential for proper Bim expression and apoptosis induction, and show that E BAB deficiency specifically impairs thymic negative selection without affecting peripheral T cell homeostasis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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