| Autor: |
Cihan Abaylı, Yusuf Kul, Muhsin Koten, Ahmet Rıfat Karasalihoğlu, Abdullah Taş, Recep Yağız, Erdoğan Bulut |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Turkish Archives of Otorhinolaryngology, Vol 55, Iss 3, Pp 99-104 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2667-7474 |
| DOI: |
10.5152/tao.2017.2391 |
| Popis: |
Objective:This study aimed to investigate possible ototoxicity associated with topical rifamycin application via electrophysiological tests and ultrastructural examinations.Methods:Electrophysiological assessment was performed with tympanometry, auditory brainstem response (ABR), and distortion product otoacoustic emission (DPOAE) measurements. This study was conducted on 40 ears of 20 guinea pigs that were detected to have normal hearing thresholds. The animals were randomly assigned to three groups: Group 1 (n=12) received 0.1 mL rifamycin, Group 2 (n=8) received 0.1 ml gentamycin, and Group 3 (n=20) received 0.1 mL physiological saline. The antibiotics and saline solutions were administered via intratympanic injections. After five injections every other day, electrophysiological tests were performed again on the 15th day. After electrophysiological measurements, the temporal bones of all guinea pigs were prepared for ultrastructural examinations and the cochlear surface morphology was examined by scanning electron microscopy (SEM).Results:The animals in group 3 did not show a statistically significant change in their DPOAE signal/noise ratio (SNR) or ABR thresholds (p>0.05). In groups 1 and 2, the reduction in the DPOAE SNR and the increase in the ABR threshold were statistically significant (p0.05).Conclusion:The results indicate that rifamycin application to the middle ears of guinea pigs has mild ototoxic effects on their inner ears. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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