Methylation Profile of Small Breast Cancer Tumors Evaluated by Modified MS–HRM

Autor:	Aleksey M. Krasnyi, Alsu A. Sadekova, Vlada V. Kometova, Valeriy V. Rodionov, Ekaterina L. Yarotskaya, Gennadiy T. Sukhikh
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	breast cancer small tumors DNA methylation GCM2 ITPRIPL1 CACNA1E Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 24, Iss 16, p 12660 (2023)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms241612660
Popis:	The DNA methylation profile of breast cancer differs from that in healthy tissues and can be used as a diagnostic and prognostic biomarker. Aim of this study: To compare the levels of gene methylation in small malignant breast cancer tumors (MAST1, PRDM14, ZNF177, DNM2, SSH1, AP2M1, CACNA1E, CPEB4, DLGAP2, CCDC181, GCM2, ITPRIPL1, POM121L2, KCNQ1, and TIMP3. Significant differences in the validation set of samples were found for seven genes; the combination of the four genes GCM2, ITPRIPL1, CACNA1E, DLGAP2 (AUC = 0.99) showed the highest diagnostic value based on logistic regression for all breast cancer samples. Our modified MS–HRM method demonstrated that small breast cancer tumors have a specific DNA methylation profile that distinguishes them from healthy tissues and benign proliferative lesions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5938f95a903d4f64803a0480803fdc7b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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