Effect of sustained experimental muscle pain on joint position sense
| Autor: | Simon J. Summers, Siobhan M. Schabrun, Rogerio P. Hirata, Thomas Graven-Nielsen, Rocco Cavaleri, Lucy S. Chipchase |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | PAIN Reports, Vol 4, Iss 3, p e737 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2471-2531 00000000 |
| DOI: | 10.1097/PR9.0000000000000737 |
| Popis: | Abstract. Introduction:. Joint position sense (JPS) is impaired in clinical musculoskeletal pain conditions, but when this impairment develops in the transition from initial to prolonged pain is not known. Objectives:. This study assessed whether progressively developing sustained experimentally induced muscle pain impacts JPS in healthy individuals. Methods:. Twenty-eight healthy individuals received injection of nerve growth factor (NGF) into the right extensor carpi radialis brevis muscle on days 0 and 2 to induce sustained pain and hyperalgesia. Wrist JPS was assessed 2 days before day 0 (day −2), before the injection on days 0 and 2, and on days 4 and 14. Joint position sense was quantified as the ability to return the wrist to a neutral position following movements in the direction of radial and ulnar deviation. A 3-dimensional motion analysis system was used to calculate absolute, relative, and joint-angle repositioning errors. Numerical rating scale scores of pain intensity, body chart pain drawings, and pressure pain thresholds (PPTs) were recorded on each day. Results:. Compared with baseline, pressure pain thresholds decreased while pain intensity and area increased at day 2 (P < 0.001) and day 4 (P < 0.001) before returning to baseline on day 14 (P > 0.13). Relative to day 0, there was no change in wrist JPS at day 2, 4, and 14 following movements in either target direction (P > 0.05). Conclusion:. Despite the presence of sustained muscle pain and hyperalgesia for 4 days at the elbow, no statistical change in wrist joint position error was observed. These findings suggest that pain and hyperalgesia lasting as long as 4 days does not impair JPS. |
| Databáze: | Directory of Open Access Journals |
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