Effect of vaporized perfluorocarbon on oxidative stress during the cold ischemia phase of lung graft preservation
| Autor: | Renata Salatti Ferrari, Leonardo Dalla Giacomassa Rocha Thomaz, Lucas Elias Lise Simoneti, Jane Maria Ulbrich, Cristiano Feijó Andrade |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Jornal Brasileiro de Pneumologia, Vol 45, Iss 4 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1806-3756 1806-3713 |
| DOI: | 10.1590/1806-3713/e20170288 |
| Popis: | ABSTRACT Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia. The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times. We performed histological analysis of and measured oxidative stress in the lungs of animals that received only preservation solution with low-potassium dextran (LPD) or vaporized PFC together with LPD. We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia. |
| Databáze: | Directory of Open Access Journals |
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