INFLUENCE OF ANTIHYPERTENSIVE THERAPY ON PSYCHOLOGICAL STATUS OF CHERNOBYL NUCLEAR POWER PLANT ACCIDENT CONSEQUENCES LIQUIDATORS
| Autor: | E. M. Manoshkina, I. I. Razdobreeva, S. K. Kukushkin |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Рациональная фармакотерапия в кардиологии, Vol 2, Iss 1, Pp 4-10 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1819-6446 2225-3653 |
| DOI: | 10.20996/1819-6446-2006-2-1-4-10 |
| Popis: | Aim. To study psychological status and influence of antihypertensive therapy (AHT) on it in Chernobyl nuclear power plant (NPP) accident consequences liquidators, who suffer arterial hyper-tension (AH), with controlled treatment compared to the standard treatment in out-patient clinic. Material and methods. 81 liquidators with AH (all men) were included into open compara-tive randomized study. Study duration was 12 months. Patients were randomized into main group (MG) and control group (CG). Patients of MG received strictly regulated stepped AHT based on ACE inhibitor spirapril 6 mg daily (Quadropril®, Pliva-AVD), hypothiazide was added if necessary (12.5-25 mg daily) and afterwards – atenolol (12.5-100 mg daily). In CG AHT and its correction was set by physician in polyclinic. Brief multifactor questionnaire for personality analysis was used to study psychological status. Results. 57 patients completed the study, 28 in MG and 29 in CG. In MG target blood pres-sure (BP) levels were reached in 22 (78.6%) patients, in CG – in 11 (38%) patients (p |
| Databáze: | Directory of Open Access Journals |
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