Determining the cytotoxicity of the Minimum Inhibitory Concentration (MIC) of silver and zinc oxide nanoparticles in ESBL and carbapenemase producing Proteus mirabilis isolated from clinical samples in Shiraz, Southwest Iran

Autor:	Farshad Kakian, Esmaeil Mirzaei, Afagh Moattari, Sara Takallu, Abdollah Bazargani
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Proteus mirabilis Drug Resistance Silver Zinc oxide Cell Culture techniques Medicine Biology (General) QH301-705.5 Science (General) Q1-390
Zdroj:	BMC Research Notes, Vol 17, Iss 1, Pp 1-6 (2024)
Druh dokumentu:	article
ISSN:	1756-0500
DOI:	10.1186/s13104-023-06402-2
Popis:	Abstract Objective Proteus mirabilis is related to serious infections. The present study was designed to investigate the minimum inhibitory concentration (MIC) of silver nanoparticles (AgNPs) and zinc oxide nanoparticles (ZnONPs) and cytotoxicity among P. mirabilis isolates recovered from clinical samples in Shiraz. Results A total of 100 P. mirabilis isolates were screened by biochemical tests and polymerase chain reaction (PCR). Also, 25 (25%) and 7 (7%) isolates were positive for extended-spectrum beta-lactamase (ESBLs) and carbapenemase, respectively. Synthesized nanoparticles were characterized by UV–vis spectrum, X-ray diffraction (XRD), and electron microscopy. The average size of AgNPs and ZnONPs in the present study is 48 and
Databáze:	Directory of Open Access Journals
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