Development of Methodic Approach to Construction of Recombinant Strain, Producer of the Cholera Toxin B Subunit

Autor:	D. S. Yanov, S. N. Klinova, A. V. Mironin, I. V. Zhivov, I. P. Pogorelsky, V. I. Drobkov, Yu. N. Feodorov, Ya. A. Kibirev
Jazyk:	ruština
Rok vydání:	2010
Předmět:	recombinant vaccine inducible expression cholera toxin b subunit vector Infectious and parasitic diseases RC109-216
Zdroj:	Проблемы особо опасных инфекций, Vol 0, Iss 4(106), Pp 62-65 (2010)
Druh dokumentu:	article
ISSN:	0370-1069 2658-719X
DOI:	10.21055/0370-1069-2010-4(106)-62-65
Popis:	Presented are the results of experiments on the construction of Escherichia coli Top10 (pTrcSuB) strain, perspective for the development of recombinant cholera vaccine for peroral use. The obtained strain possesses inducible expression of cholera toxin B subunit. Peculiarities of cloned gene expression in strain-producer and the conditions of its maintaining were studied. The proposed approach will allow to obtain effective and safe cholera vaccines.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/5748d708c94a47299f0b965cf9a2c974 Zobrazit plný text záznamu View record in DOAJ