| Autor: |
Heidi T May, Kirk U Knowlton, Joseph B Muhlestein, Jeffrey L Anderson, Benjamin D Horne, Susan Rea, Tami L Bair, Colin K Grissom, Ithan D Peltan, Joseph R Bledsoe, Brandon J Webb, John F Carlquist, Sterling T Bennett, Stacey Knight, Brianna S Ronnow, Viet T Le, Edward Stenehjem, Scott C Woller |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
BMJ Open, Vol 12, Iss 3 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2021-053864 |
| Popis: |
Objectives The Intermountain Risk Score (IMRS), composed using published sex-specific weightings of parameters in the complete blood count (CBC) and basic metabolic profile (BMP), is a validated predictor of mortality. We hypothesised that IMRS calculated from prepandemic CBC and BMP predicts COVID-19 outcomes and that IMRS using laboratory results tested at COVID-19 diagnosis is also predictive.Design Prospective observational cohort study.Setting Primary, secondary, urgent and emergent care, and drive-through testing locations across Utah and in sections of adjacent US states. Viral RNA testing for SARS-CoV-2 was conducted from 3 March to 2 November 2020.Participants Patients aged ≥18 years were evaluated if they had CBC and BMP measured in 2019 and tested positive for COVID-19 in 2020.Primary and secondary outcome measures The primary outcome was a composite of hospitalisation or mortality, with secondary outcomes being hospitalisation and mortality separately.Results Among 3883 patients, 8.2% were hospitalised and 1.6% died. Subjects with low, mild, moderate and high-risk IMRS had the composite endpoint in 3.5% (52/1502), 8.6% (108/1256), 15.5% (152/979) and 28.1% (41/146) of patients, respectively. Compared with low-risk, subjects in mild-risk, moderate-risk and high-risk groups had HR=2.33 (95% CI 1.67 to 3.24), HR=4.01 (95% CI 2.93 to 5.50) and HR=8.34 (95% CI 5.54 to 12.57), respectively. Subjects aged |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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