| Autor: |
Nathan John Hanan, Mary Elizabeth Paul, Yanling Huo, Suad Kapetanovic, Elizabeth Smith, George Siberry, Pim Brouwers, Bobbie Graham, Benjamin Johnston, Edmund V. Capparelli, Brookie M. Best |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Frontiers in Pediatrics, Vol 7 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2296-2360 |
| DOI: |
10.3389/fped.2019.00016 |
| Popis: |
Objective: Due to potential disease and drug interactions, the appropriate sertraline starting dose and titration range may require adjustment in pediatric patients living with HIV. This is the first report of sertraline pharmacokinetics in HIV-infected youth.Methods: IMPAACT P1080 was a multicenter pilot study describing psychiatric medication pharmacokinetics in HIV-infected and uninfected youth. Participants were stable on sertraline, >6 to -0.5).Conclusions: HIV(–) cohort had the highest sertraline exposure. Sertraline exposure was ~40% lower in the PI/r cohort than in HIV(–); the need to alter sertraline dose ranges for PI/r participants is not clear. The impact of efavirenz on sertraline needs further investigation due to limited numbers of EFV participants. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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