| Autor: |
Kailas K. Moravkar, Umesh D. Laddha, Mahesh D. Patil, Sharad S. Kale, Nikhil Girase, Bhushan A. Bhairav, Jayeeta Bhaumik, Shailesh S. Chalikwar |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Carbohydrate Polymer Technologies and Applications, Vol 5, Iss , Pp 100320- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-8939 |
| DOI: |
10.1016/j.carpta.2023.100320 |
| Popis: |
The present study narrates the extraction of rutin from Tagetes erecta (Marigold) via maceration followed by ultrasonication. The extracted rutin was further fabricated into nanoparticles by high-pressure homogenization (HPH) and assessed by HPLC, DSC, XRD, TEM, and FTIR spectroscopy. The optimized batch of nanoparticles obtained using 32 central composite design (CCD) which exhibited particle size 209±14 nm, PDI 0.234±0.06, and 92±1.3% entrapment efficiency. The lyophilized rutin nanoparticles were further converted into nano-suspension. Interestingly, the rutin nano-suspension exhibited a similar antitussive effect in vivo as that by standard treatment pentoxyverine and reduced the coughing times within 2 min. Also, the phlegm showed high UV absorbance, implying its better expectorant activity than the standard and control. The rutin nano-suspension was highly stable and shelf life was found to be ∼29.1 months. The present study, for the first time, paves a way for the use of rutin nano-suspension to overcome chest congestion, shortening of breath, and in the management of cough. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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