The Role of Tissue Engineering and Three-Dimensional–Filled Conduits in Bridging Nerve Gaps: A Review of Recent Advancements

Autor: Bryan S. Crook, MD, Mark M. Cullen, MD, Tyler S. Pidgeon, MD
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Hand Surgery Global Online, Vol 6, Iss 5, Pp 700-704 (2024)
Druh dokumentu: article
ISSN: 2589-5141
DOI: 10.1016/j.jhsg.2024.01.024
Popis: Tissue-engineered nerve guidance conduits (NGCs) are an area of research interest and investment. Currently, two separate three-dimensional, filled NGCs have Food and Drug Administration approval in the management of nerve gaps up to 3 cm in length, with more on the horizon. Future NGC options will leverage increasingly intricate designs to mimic the natural biology and architecture of native nerve tissue. To enhance the development of next-generation NGCs, experimental protocols and models should be standardized. For the NGCs currently on the market, more clinical data and randomized comparative studies are needed.
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